Can You Take Polyphenols with Saponin?

When taken together, polyphenols and saponin do not seem to interact in a way that would cause concern. Research has shown that they can work together to inhibit the growth of certain fungi, but this is not directly relevant to human supplement use. Overall, the available evidence suggests that they can be taken together without issue. No mechanism of interaction was identified. However, both polyphenols and saponin have been shown to have antifungal properties, and their combination may enhance this effect through a synergistic interaction. This means that they may work together to achieve a greater effect than either would alone.