Can You Take Malic Acid with Vitamin C?
Malic Acid and Vitamin C appear to be safe taken together.
Vitamin C redox state change
Malic Acid and Vitamin C appear to be safe taken together.
Vitamin C redox state change
Detailed Analysis
Research on animals suggests that taking Malic Acid with Vitamin C may increase levels of reduced Vitamin C in the blood and decrease levels of oxidized Vitamin C. This interaction seems to occur in the context of metabolic pathways involving malate dehydrogenase. However, no direct human studies were found. The biochemical mechanism behind this interaction involves the malate dehydrogenase reaction, which may influence the redox state of Vitamin C. Malate dehydrogenase is an enzyme that catalyzes the conversion of malate to oxaloacetate, producing NADH from NAD+ in the process. This reaction may indirectly affect Vitamin C metabolism by altering the availability of reducing equivalents.
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Research Sources (2)
This information is for educational purposes only and is not a substitute for professional medical advice. Always consult your healthcare provider before starting, stopping, or changing any supplement regimen.