Can You Take Glycine with Glycocyamine?

When taken together, glycine and glycocyamine do not seem to interact in a way that would cause concern. The body uses glycine to make glycocyamine, which is then converted into creatine, an important energy source for muscles. No significant interaction has been identified. Glycine is an amino acid that serves as a substrate for the enzyme glycine-amidinotransferase (GAT), which catalyzes the formation of guanidinoacetic acid (GAA), a precursor to creatine. Glycocyamine, another name for GAA, is directly involved in creatine synthesis. The biochemical pathway does not suggest a direct interaction that would be concerning.