Can You Take Gamma-Aminobutyric Acid with St John's Wort?
St John's Wort may alter GABA effects, requiring dose adjustments.
GABA activity alteration
St John's Wort may alter GABA effects, requiring dose adjustments.
GABA activity alteration
Detailed Analysis
Taking St John's Wort with GABA supplements may change how GABA works in the body. This can lead to increased sedation or mood changes. Monitoring and possible dose adjustments are recommended. St John's Wort influences GABA activity by affecting neurotransmitter levels in the brain. It induces certain enzyme expressions that can alter GABA's inhibitory effects. This may lead to changes in sedation or mood.
What else do you take?
2/10Check your full stack — every pair, not just this one
Optimal Timing
⏱️ St John's Wort separated from Gamma-Aminobutyric Acid by 9h (St. John's Wort is known to influence the activity of various neurotransmitters,)
Research Sources (2)
This information is for educational purposes only and is not a substitute for professional medical advice. Always consult your healthcare provider before starting, stopping, or changing any supplement regimen.