Can You Take Creatine with Selenium?

Research on creatine and selenium supplementation suggests that they do not interact negatively when taken together. Studies have explored the effects of creatine on exercise performance and muscle creatine levels, but none have indicated a significant interaction with selenium. Therefore, individuals can likely take these supplements concurrently without major concerns. There is no known biochemical mechanism by which creatine and selenium interact. Creatine works by increasing muscle creatine phosphate levels, enhancing ATP production during high-intensity activities. Selenium, on the other hand, functions as an antioxidant, protecting cells from damage. Their mechanisms of action do not overlap or interfere with each other.