Can You Take Creatine with Gamma-Aminobutyric Acid?

Taking creatine and GABA together may lead to a small reduction in GABA levels. This could potentially affect the balance of neurotransmitters in the brain. However, the effect is likely to be mild and may not cause noticeable symptoms. Creatine may decrease the activity of glutamate decarboxylase, the enzyme responsible for converting glutamate into GABA. This reduction in enzyme activity could lead to lower GABA levels. Glutamate decarboxylase is a crucial enzyme in the synthesis of GABA, a major inhibitory neurotransmitter.