Can You Take Citrulline with Valine?
Valine may reduce Citrulline effectiveness
Reduced Citrulline effectiveness
Valine may reduce Citrulline effectiveness
Reduced Citrulline effectiveness
Detailed Analysis
Taking Citrulline and Valine together may affect how well Citrulline works. Valine can interfere with an enzyme that helps Citrulline function properly. This might impact the benefits you're seeking from Citrulline. Valine competitively inhibits the enzyme activity at low concentrations of L-citrulline. This means that Valine competes with Citrulline for a specific enzyme, argininosuccinate synthetase, which is needed to process Citrulline. The Ki value of 6.0 x 10^(-4) M indicates the strength of this interaction.
What else do you take?
2/10Check your full stack — every pair, not just this one
Optimal Timing
⏱️ Valine separated from Citrulline by 5.5h (Valine competitively inhibits the enzyme activity at low concentrations of L-cit)
Research Sources (2)
This information is for educational purposes only and is not a substitute for professional medical advice. Always consult your healthcare provider before starting, stopping, or changing any supplement regimen.