Can You Take Citrulline with Lysine?
Citrulline and Lysine appear to be safe taken together.
Kidney transport interaction
Citrulline and Lysine appear to be safe taken together.
Kidney transport interaction
Detailed Analysis
Research indicates that taking citrulline and lysine supplements together does not cause significant interactions. Studies have shown that lysine can inhibit the transport of citrulline in the kidneys, but this does not seem to have major implications for most people. Overall, the combination is considered safe. The biochemical mechanism involves the transport of amino acids in the kidneys. Lysine, being a dibasic amino acid, can inhibit the transport system that citrulline uses. However, this interaction does not appear to have significant effects on the body's overall function.
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Research Sources (3)
This information is for educational purposes only and is not a substitute for professional medical advice. Always consult your healthcare provider before starting, stopping, or changing any supplement regimen.