Can You Take Citrulline with Isoleucine?
Citrulline and Isoleucine may interact, affecting citrulline metabolism.
Isoleucine inhibits Citrulline metabolism
Citrulline and Isoleucine may interact, affecting citrulline metabolism.
Isoleucine inhibits Citrulline metabolism
Detailed Analysis
When taken together, Isoleucine may competitively inhibit the enzyme activity involved in Citrulline metabolism. This could potentially reduce the effectiveness of Citrulline supplementation. The interaction may require consideration of dosing timing. Isoleucine competitively inhibits argininosuccinate synthetase, an enzyme involved in Citrulline metabolism, with a Ki value of 6.3 x 10(-4) M. This means Isoleucine competes with Citrulline for the active site on the enzyme, potentially reducing Citrulline's metabolic effects.
What else do you take?
2/10Check your full stack — every pair, not just this one
Optimal Timing
⏱️ Isoleucine separated from Citrulline by 5.5h (Isoleucine competitively inhibits the enzyme activity at low concentrations of L)
Research Sources (1)
This information is for educational purposes only and is not a substitute for professional medical advice. Always consult your healthcare provider before starting, stopping, or changing any supplement regimen.