Can You Take Citrulline with Histidine?
Histidine may affect Citrulline levels in the body.
Citrulline level reduction
Histidine may affect Citrulline levels in the body.
Citrulline level reduction
Detailed Analysis
When taking Citrulline and Histidine together, Histidine may reduce the amount of Citrulline available in the body. This could impact the benefits of Citrulline supplementation. Monitoring Citrulline levels or adjusting dosing may be necessary. Histidine can inhibit the saturable uptake of Citrulline, which means it may block some of Citrulline's absorption into cells. This is likely due to competition for transport mechanisms in the body. As a result, taking Histidine with Citrulline may decrease Citrulline's effectiveness.
What else do you take?
2/10Check your full stack — every pair, not just this one
Optimal Timing
⏱️ Histidine separated from Citrulline by 5.5h (Histidine inhibits the saturable uptake of citrulline, as demonstrated in a stud)
Research Sources (2)
This information is for educational purposes only and is not a substitute for professional medical advice. Always consult your healthcare provider before starting, stopping, or changing any supplement regimen.