Can You Take Caffeine with Creatine Monohydrate?

Research suggests that taking caffeine and creatine monohydrate together does not cause significant interactions. A study published in the European Journal of Applied Physiology found no adverse effects on intermittent high-intensity sprint performance when creatine-loaded participants ingested caffeine. This indicates that co-administration of these two supplements is likely safe for physically active individuals. No direct biochemical mechanism of interaction was reported between caffeine and creatine monohydrate. Caffeine works by blocking adenosine receptors, while creatine monohydrate increases muscle creatine levels. Their mechanisms of action do not directly overlap, which may explain the lack of interaction.