Can You Take Arginine with Copper?

SERIOUS INTERACTION

Arginine and Copper may interact harmfully

6 studies

Strong evidence

DNA damage and oxidative stress

SERIOUS INTERACTION

Arginine and Copper may interact harmfully

•

6 studies

•

Strong evidence

DNA damage and oxidative stress

Detailed Analysis

✓ Complete

Taking arginine and copper supplements together may cause adverse effects. Copper can increase oxidative stress, while arginine may enhance copper's DNA-damaging activity. This interaction may lead to serious health problems. Copper can increase malondialdehyde and reactive oxygen species, which are unstable molecules that can damage cells. Arginine may enhance the DNA cleaving activity of copper, meaning it can make copper more likely to damage DNA. This can lead to cell death and other health issues.

What else do you take?

2/10

Check your full stack — every pair, not just this one

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Related Interactions

Copper + Iron

Moderate

Arginine + Citrulline

Beneficial

Copper + Manganese

Moderate

Arginine + Asymmetric Dimethylarginine

Research Sources (6)

Copper binding dynamics and olfactory impairment in fathead minnows (Pimephales promelas).

Environmental science & technology · 2010 · PMID: 20102182

The effects of L-arginine, alone and combined with vitamin C, on mineral status in relation to its antidiabetic, anti-inflammatory, and antioxidant properties in male rats on a high-fat diet.

Biological trace element research · 2014 · PMID: 24293384

Copper-induced tight junction mRNA expression changes, apoptosis and antioxidant responses via NF-κB, TOR and Nrf2 signaling molecules in the gills of fish: preventive role of arginine.

Aquatic toxicology (Amsterdam, Netherlands) · 2015 · PMID: 25461751

A paradoxical relationship between Resveratrol and copper (II) with respect to degradation of DNA and RNA.

This information is for educational purposes only and is not a substitute for professional medical advice. Always consult your healthcare provider before starting, stopping, or changing any supplement regimen.