Can You Take Alpha-Ketoglutaric Acid with Glutamate?

Taking Alpha-Ketoglutaric Acid and Glutamate together does not seem to cause any significant issues. Research shows that alpha-ketoglutarate can inhibit certain enzymes, but this does not appear to have a major impact when taken with Glutamate. Overall, no major concerns are raised when combining these two supplements. The biochemical mechanism involves alpha-ketoglutarate's ability to inhibit pyruvate carboxylase, an enzyme involved in gluconeogenesis. However, this interaction does not seem to have significant implications for Glutamate metabolism. A technical term to note is gluconeogenesis, which is the process by which the body generates glucose from non-carbohydrate sources.