Can You Take Adenosine with Citicholine?

Taking adenosine and citicoline supplements together does not seem to cause any significant interactions. The available research does not indicate any adverse effects or benefits from combining these two supplements. You can likely take them together without concern. No mechanism of interaction was identified between adenosine and citicoline. However, both supplements are involved in different biochemical pathways. Adenosine is a nucleoside involved in energy transfer, while citicoline (CDP-choline) is a precursor to phospholipids in cell membranes. One study showed that oral uridine-5'-monophosphate (UMP) increases brain CDP-choline levels, but there is no direct link to adenosine.