Can You Take 5-Hydroxytryptophan with Proline?
5-Hydroxytryptophan may reduce Proline absorption
Reduced Proline absorption
5-Hydroxytryptophan may reduce Proline absorption
Reduced Proline absorption
Detailed Analysis
Taking 5-Hydroxytryptophan and Proline together may decrease the absorption of Proline. This could potentially impact various bodily functions that rely on Proline. Individuals taking Proline supplements or medications may need to adjust their regimen. 5-Hydroxytryptophan inhibits the uptake of L-Proline with an IC50 of 1.6 ± 0.4 mM, likely through interaction with the amino acid transporter PAT2. PAT2 plays a role in amino acid reabsorption in the renal proximal tubule.
What else do you take?
2/10Check your full stack — every pair, not just this one
Optimal Timing
⏱️ Proline separated from 5-Hydroxytryptophan by 5.5h (5-Hydroxytryptophan inhibits l-proline uptake with an IC50 of 1.6 ± 0.4 mM.)
Research Sources (1)
This information is for educational purposes only and is not a substitute for professional medical advice. Always consult your healthcare provider before starting, stopping, or changing any supplement regimen.